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Generic Name: Sulphadoxine + Pyrimethamine
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✅ Description:
Sulphadoxine & Pyrimethamine is an antimalarial agent embodying the concept of synergism. Individually the components of this preparation exert inferior result with higher doses in comparison with that obtained with the combination. Moreover, this preparation is effective against strains that are resistant to other antimalarial agents and the risk of resistance development is minimum with this preparation. It is extremely long acting drug, attacks the different development stages of the parasite and attains effective concentration with a single dose. The protective effect of a single dose lasts for approximately four weeks and this preparation is compatible with other antimalarial drugs and with antibiotics. It does not influence the action of antidiabetic agents.
Treatment of all forms of malaria due to Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae. The drug is also used for suppressive or prophylactic management, particularly in areas where resistance to chloroquine is known to exist.
Sulphadoxine + Pyrimethamine dosage
Curative treatment of malaria with a single dose-
Adults: 2-3 tablets
Children under 4 years: ½ tablets
4-8 years: 1 tablet
9-14 years: 2 tablets
In severe cases, Sulphadoxine & Pyrimethamine can be beneficially combined with quinine.
Suppressive or prophylactic management-
The dose given below should be taken at one time:For semi-immune subjects (
Dose: once every four weeks)-
Adults: 2-3 tablets
Children under 4 years: ½ tablets
4-8 years: 1 tablet
9-14 years: 2 tablets
For non-immune subjects (
Dose: Once every two weeks)-
Adults: 2 tablets
Children under 4 years: 1½ tablets
4-8 years: 1 tablet
9-14 years: 1½ tablets
For malaria prophylaxis: The first dose of Sulphadoxine & Pyrimethamine should be taken one or two days before departure for an endemic area in order to protect tolerance, administration should be continued in the above dosage during the stay and also for four weeks after return or as prescribed by the physician.
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